Abstract
Gammadelta T lymphocytes and CD1d-restricted natural killer T cells are classified as innate T lymphocytes, which perform effector functions that protect from malignancy and maintain tissue integrity. Innate T cells also play important regulatory roles in autoimmunity, inflammation and infection. Recent advances have established innate T cells as both effectors and regulators of disease in biological models.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens, CD1 / analysis*
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Antigens, CD1d
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Apoptosis
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Autoimmune Diseases / immunology
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Homeostasis
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Infections / immunology
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Inflammation Mediators / physiology
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Killer Cells, Natural / immunology
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Neoplasms / immunology
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Receptors, Antigen, T-Cell, gamma-delta / analysis*
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T-Lymphocyte Subsets / classification
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T-Lymphocyte Subsets / immunology*
Substances
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Antigens, CD1
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Antigens, CD1d
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Inflammation Mediators
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Receptors, Antigen, T-Cell, gamma-delta