Abstract
Cutaneous squamous cell carcinoma is typically characterized by the over-expression of the tumour suppressor protein p53. Considerable evidence suggests that immune competence is important in the control of cutaneous SCC. We discuss the immunobiology of p53 and its relevance to cutaneous SCC, including the potential interaction with human papillomavirus.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Carcinoma, Squamous Cell / immunology*
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Carcinoma, Squamous Cell / virology
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Humans
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Immunocompetence
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Papillomaviridae
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Papillomavirus Infections / complications
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Skin Neoplasms / immunology*
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Skin Neoplasms / virology
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Tumor Suppressor Protein p53 / immunology*
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Tumor Virus Infections / complications
Substances
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Tumor Suppressor Protein p53