Marine natural products as lead anti-HIV agents

Mini Rev Med Chem. 2003 Aug;3(5):401-24. doi: 10.2174/1389557033487962.

Abstract

Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / pharmacology*
  • Biological Products / chemistry
  • Biological Products / pharmacology*
  • Humans
  • Marine Biology
  • Structure-Activity Relationship

Substances

  • Anti-HIV Agents
  • Biological Products