Sclerotherapy in aneurysmal bone cysts in children: a review of 17 cases

Pediatr Radiol. 2003 Jun;33(6):365-72. doi: 10.1007/s00247-003-0899-4. Epub 2003 Mar 22.

Abstract

Objective: To determine the efficacy of percutaneous sclerotherapy in the treatment of aneurysmal bone cysts.

Materials and methods: Seventeen patients (7 girls, 10 boys) with aneurysmal bone cysts were treated by the percutaneous approach with Ethibloc ( n=14) and histoacryl glue ( n=3) in our institution between January 1994 and June 2000. The cysts were located in the extremities ( n=6), pelvis ( n=2), spine ( n=2), mandible ( n=5), rib ( n=1) and sphenoid bone ( n=1). Percutaneous sclerotherapy was performed with fluoroscopic and/or computed tomographic guidance under general anesthesia. Clinical and imaging follow-up lasted from 24 months to 9 years and 6 months (mean: 57.3 months). The results were quantified as: excellent (residual cyst less than 20% of the initial involvement), satisfactory (residual cyst 30-50%), unsatisfactory (residual cyst more than 50%).

Results: The age of the patients ranged from 4 years and 6 months to 15 years and 8 months (mean: 11 years and 2 months). In nine patients, the therapeutic procedure was repeated 2-5 times. Excellent regression was observed in 16 (94%), satisfactory results in 1 (6%). There was no failure (unsatisfactory result or no response to treatment) in this reported series. The complications were minor and included: local inflammatory reaction ( n=2), small blister ( n=1), and leakage ( n=1). Relief of symptoms was achieved in all patients. No recurrence was noted during follow-up.

Conclusion: Percutaneous sclerotherapy of aneurysmal bone cysts with Ethibloc is safe and effective. It is an important alternative to surgery, especially when surgery is technically impossible or not recommended in high-risk patients.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Bone Cysts, Aneurysmal / diagnostic imaging*
  • Bone Cysts, Aneurysmal / physiopathology
  • Bone Cysts, Aneurysmal / therapy*
  • Child
  • Child, Preschool
  • Diatrizoate / therapeutic use*
  • Drug Combinations
  • Fatty Acids / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Propylene Glycols / therapeutic use*
  • Risk Assessment
  • Sclerosing Solutions / therapeutic use
  • Sclerotherapy / methods*
  • Severity of Illness Index
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Zein / therapeutic use*

Substances

  • Drug Combinations
  • Fatty Acids
  • Propylene Glycols
  • Sclerosing Solutions
  • Diatrizoate
  • Zein
  • alcoholic prolamine solution