Hallmarks of Caenorhabditis elegans N-glycosylation: complexity and controversy

Biochimie. 2003 Jan-Feb;85(1-2):25-32. doi: 10.1016/s0300-9084(03)00041-5.

Abstract

Caenorhabditis elegans has become one of the most widely used model organisms for a range of molecular cell biological applications and is being increasingly used by glycobiologists. However, a major problem has been the lack of knowledge of the structure of the protein-linked glycans from this organism. In recent years several groups have published structural data, particularly N-glycan structural data. However, some of these data are contradictory. In this review we critically assess all the N-glycan structural data and consider how close we are in our goal of defining the glycome of C. elegans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / chemistry
  • Caenorhabditis elegans / metabolism*
  • Glycosylation
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry / methods
  • Molecular Structure
  • Polysaccharides / chemistry
  • Polysaccharides / classification
  • Polysaccharides / isolation & purification*

Substances

  • Polysaccharides