New antimalarial bis-dehydroaporphine alkaloids from Polyalthia debilis

J Nat Prod. 2003 May;66(5):616-9. doi: 10.1021/np020498d.

Abstract

Four new dimeric aporphinoids named bidebilines A-D (1-4), bis-7,7'-dehydroanonaine (1), 7-dehydroanonaine-7'-dehydro-8'-methoxyanonaine (2), bis-7,7'-dehydro-8,8'-dimethoxyanonaine (3), and bis-7,7'-dehydro-10,10'-dimethoxyanonaine (4), were isolated from the roots of Polyalthia debilis. Their structures were established on the basis of spectral evidence. Compounds 3 and 4 exhibited moderate antimalarial activity with IC(50) values of 5.4 and 4.1 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology
  • Inhibitory Concentration 50
  • Molecular Structure
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Plasmodium falciparum / drug effects
  • Polyalthia / chemistry*
  • Thailand

Substances

  • Alkaloids
  • Antimalarials