Excitement reduces inhibition via endocannabinoids

Neuron. 2003 May 8;38(3):362-5. doi: 10.1016/s0896-6273(03)00262-9.

Abstract

Previous work has suggested a role for retrograde synaptic signaling via endogenous cannabinoids in regulating the inhibitory control of neuronal activity. In this issue of Neuron, Chevaleyre and Castillo provide evidence for another form of endocannabinoid-mediated depression of hippocampal inhibition, which is activity dependent and long lasting.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Cannabinoid Receptor Modulators
  • Endocannabinoids
  • Fatty Acids, Unsaturated / metabolism*
  • Hippocampus / metabolism*
  • Humans
  • Long-Term Synaptic Depression / physiology*
  • Neural Inhibition / physiology*
  • Presynaptic Terminals / metabolism*
  • Receptors, Cannabinoid
  • Receptors, Drug / metabolism
  • Receptors, Glutamate / metabolism
  • Synaptic Transmission / physiology*
  • gamma-Aminobutyric Acid / metabolism

Substances

  • Cannabinoid Receptor Modulators
  • Endocannabinoids
  • Fatty Acids, Unsaturated
  • Receptors, Cannabinoid
  • Receptors, Drug
  • Receptors, Glutamate
  • gamma-Aminobutyric Acid