[Botulism toxin, bioterrorist weapon]

Presse Med. 2003 Mar 15;32(10):463-5.
[Article in French]

Abstract

BOTULISM AND BIOWARFARE: Botulism is a severe neuro-paralysing infection due to a toxin produced by Clostridium botulinum. The use of the botulinum toxin for terrorist aims in the form of aerosols is a perfectly credible eventuality. The botulinum toxin is the most potent toxin known; it is easy to produce and can lead to massive destruction.

Depending on the contamination: The clinical forms of botulism depend on the mode of contamination. Botulism through inhalation can only be the result of a deliberate act using an aerosol. The clinical symptomatology is identical to that of the other forms.

Prevention: In the case of a bio-terrorist attack with an aerosol of botulinum toxin, the subjects exposed should be vaccinated as a prophylactic measure with trivalent antitoxin vaccine (types A, B and E). This vaccine must be administered as rapidly as possible in symptomatic patients. A single case of botulism acquired by inhalation corresponds to an act of terrorism.

Publication types

  • English Abstract

MeSH terms

  • Administration, Oral
  • Aerosols
  • Bacterial Vaccines / administration & dosage
  • Biological Warfare*
  • Botulinum Antitoxin / administration & dosage
  • Botulinum Toxins / toxicity*
  • Botulism / diagnosis
  • Botulism / prevention & control
  • Botulism / transmission*
  • Humans
  • Risk Assessment
  • Terrorism*

Substances

  • Aerosols
  • Bacterial Vaccines
  • Botulinum Antitoxin
  • Botulinum Toxins