Chimeric nucleases stimulate gene targeting in human cells

Science. 2003 May 2;300(5620):763. doi: 10.1126/science.1078395.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • DNA / metabolism
  • Deoxyribonucleases, Type II Site-Specific / chemistry
  • Deoxyribonucleases, Type II Site-Specific / genetics
  • Deoxyribonucleases, Type II Site-Specific / metabolism*
  • Dimerization
  • Gene Targeting / methods*
  • Green Fluorescent Proteins
  • Humans
  • Luminescent Proteins / genetics
  • Mutation
  • Nuclear Localization Signals
  • Recombinant Fusion Proteins / chemistry
  • Recombinant Fusion Proteins / metabolism*
  • Recombination, Genetic
  • Saccharomyces cerevisiae Proteins
  • Transfection
  • Zinc Fingers*

Substances

  • Luminescent Proteins
  • Nuclear Localization Signals
  • Recombinant Fusion Proteins
  • Saccharomyces cerevisiae Proteins
  • Green Fluorescent Proteins
  • DNA
  • SCEI protein, S cerevisiae
  • endodeoxyribonuclease FokI
  • Deoxyribonucleases, Type II Site-Specific