Abstract
Novel quinolone-macrocycle conjugates displayed submicromolar antibacterial activity against Escherichia coli and Staphylococcus aureus bacterial strains. An analogous open-chain structure was not active at 100 microM against the same pathogenic strains.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Escherichia coli / drug effects
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Heterocyclic Compounds / chemistry
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Heterocyclic Compounds / pharmacology*
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Microbial Sensitivity Tests
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Quinolones / chemistry
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Quinolones / pharmacology*
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Staphylococcus aureus / drug effects
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Heterocyclic Compounds
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Quinolones