One-shot memory in hippocampal CA3 networks

Neuron. 2003 Apr 24;38(2):147-8. doi: 10.1016/s0896-6273(03)00227-7.

Abstract

The hippocampus plays a crucial role in the encoding and retrieval of episodic memory. In this issue of Neuron, Nakazawa and coworkers show that synaptic modification in hippocampal CA3 neurons is critical for immediate storage of information, a key feature of episodic memory.

Publication types

  • Comment

MeSH terms

  • Animals
  • Hippocampus / cytology
  • Hippocampus / physiology*
  • Long-Term Potentiation / physiology
  • Maze Learning
  • Memory / physiology*
  • Mice
  • Mutation
  • Nerve Net / cytology
  • Nerve Net / physiology*
  • Neurons / physiology*
  • Pyramidal Cells / metabolism
  • Pyramidal Cells / physiology
  • Receptors, N-Methyl-D-Aspartate / genetics
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Synapses / physiology*

Substances

  • NR1 NMDA receptor
  • Receptors, N-Methyl-D-Aspartate