Reactivity toward oxygen of isobenzofuranyl radicals: effect of nitro group substitution

Org Lett. 2003 May 1;5(9):1515-8. doi: 10.1021/ol034307p.

Abstract

The presence of a nitro group in the p-phenyl position dramatically slows down the oxygenation of isobenzofuranyl radicals. However, both unsubstituted and m-substituted phenyl rings have no appreciable influence on the reactivity toward oxygen. Spin delocalization on the nitro group is proposed to explain the stability of the carbon-centered radical generated. [reaction: see text]