Synthesis of novel acetylene-containing amino acids

Amino Acids. 2003 Apr;24(3):263-6. doi: 10.1007/s00726-002-0408-3.

Abstract

Novel synthetic procedures for the modification of non-proteinogenic acetylene-containing amino acids have been developed. The functionalization either proceeds via zinc/copper-mediated introduction of alkyl substituents, or via tungsten-catalyzed ring-closing alkyne metathesis reactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylene / chemistry*
  • Amino Acids / chemical synthesis*
  • Amino Acids / chemistry
  • Catalysis
  • Copper / chemistry
  • Models, Chemical
  • Zinc / chemistry

Substances

  • Amino Acids
  • Copper
  • Zinc
  • Acetylene