Abstract
The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.
MeSH terms
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Alkyl and Aryl Transferases / antagonists & inhibitors*
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Azepines / chemical synthesis*
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Azepines / chemistry
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Azepines / pharmacology
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Farnesyltranstransferase
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Humans
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In Vitro Techniques
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Indicators and Reagents
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Mice
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Microsomes, Liver / drug effects
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Microsomes, Liver / metabolism
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Quinazolines / chemical synthesis
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Quinazolines / chemistry*
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Quinazolines / pharmacology
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Quinolones / chemical synthesis
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Quinolones / chemistry*
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Quinolones / pharmacology
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Structure-Activity Relationship
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Xenograft Model Antitumor Assays
Substances
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Antineoplastic Agents
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Azepines
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Indicators and Reagents
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Quinazolines
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Quinolones
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Alkyl and Aryl Transferases
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Farnesyltranstransferase
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tipifarnib