Molecular characterization of the porcine gene CAPNS1 encoding the small subunit 1 of calpain on SSC6q1.1-->q1.2

C Drögemüller; T Leeb

doi:10.1159/000069809

Molecular characterization of the porcine gene CAPNS1 encoding the small subunit 1 of calpain on SSC6q1.1-->q1.2

Cytogenet Genome Res. 2002;98(2-3):206-9. doi: 10.1159/000069809.

Authors

C Drögemüller¹, T Leeb

Affiliation

¹ Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Hannover, Germany.

PMID: 12698005
DOI: 10.1159/000069809

Abstract

The CAPNS1 gene encodes the small subunit of the calpain proteases. Cloning and characterization of the porcine CAPNS1 gene revealed a highly conserved organization with respect to other mammalian CAPNS1 orthologs. The porcine gene consists of 11 exons spanning approximately 7.3 kb and codes for a peptide of 266 amino acids. Analysis of the naturally occurring variation of the CAPNS1 gene in different pig breeds revealed six SNPs and four small insertion/deletion polymorphisms. The CAPNS1 gene is located immediately adjacent to the COX7A1 gene on SSC6q1.1-->q1.2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Base Sequence
Calpain / genetics*
Chromosomes, Mammalian
Gene Components
Polymorphism, Genetic
Protein Subunits
RNA Splice Sites
Swine / genetics*

Substances

Protein Subunits
RNA Splice Sites
Calpain