Usefulness of RA and RO isoforms of common leukocyte antigen (CD45) for early distinction between normal and abnormal promyelocytes

Leuk Lymphoma. 2002 Sep;43(9):1823-5. doi: 10.1080/1042819021000006538.

Abstract

Normal promyelocytes express CD45RO, while acute promyelocytic leukemia (APL) blasts express CD45RA, both isoforms of common leukocyte antigen with mutually exclusive expression. Here we report a patient with accumulation of promyelocytes in the bone marrow and the diagnostic strategy is described along with the ability to quickly discriminate between normal and abnormal cells using the flow cytometric detection of expression of RA/RO isoforms of CD45.

Publication types

  • Case Reports

MeSH terms

  • Bone Marrow Cells / metabolism
  • Female
  • Flow Cytometry
  • Granulocyte Precursor Cells / metabolism*
  • Humans
  • Immunophenotyping
  • Leukemia, Promyelocytic, Acute / diagnosis*
  • Leukemia, Promyelocytic, Acute / metabolism*
  • Leukocyte Common Antigens / chemistry*
  • Middle Aged
  • Protein Isoforms

Substances

  • Protein Isoforms
  • Leukocyte Common Antigens