The prevention of preterm labour -- corticotropin releasing hormone type 1 receptors as a target for drug design and development

Mini Rev Med Chem. 2003 Jun;3(4):295-303. doi: 10.2174/1389557033488105.

Abstract

The role of the corticotropin releasing hormone in the onset of labour and the subsequent medicinal chemistry implications of CRH antagonists for the prevention of premature birth, and identification of the CRH type 1 receptor as the target for this drug design, are reviewed here.

Publication types

  • Review

MeSH terms

  • Adult
  • Amino Acid Sequence
  • CRF Receptor, Type 1
  • Corticotropin-Releasing Hormone / physiology
  • Corticotropin-Releasing Hormone / therapeutic use*
  • Drug Design
  • Female
  • Humans
  • Molecular Sequence Data
  • Obstetric Labor, Premature / prevention & control*
  • Pregnancy
  • Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors*

Substances

  • Receptors, Corticotropin-Releasing Hormone
  • CRF Receptor, Type 1
  • Corticotropin-Releasing Hormone