Expression of cycloxygenase-2 in human bladder and renal cell carcinoma

Shuntaro Hara; Yukihiro Kondo; Ichiro Matsuzawa; Yoshitaka Hashimoto; Go Kimura; Masaso Akimoto; Nobumasa Imura

doi:10.1007/978-1-4615-0193-0_20

Expression of cycloxygenase-2 in human bladder and renal cell carcinoma

Adv Exp Med Biol. 2002:507:123-6. doi: 10.1007/978-1-4615-0193-0_20.

Authors

Shuntaro Hara¹, Yukihiro Kondo, Ichiro Matsuzawa, Yoshitaka Hashimoto, Go Kimura, Masaso Akimoto, Nobumasa Imura

Affiliation

¹ Kitasato University, School of Pharmaceutical Sciences, Tokyo 108-8641, Japan.

PMID: 12664575
DOI: 10.1007/978-1-4615-0193-0_20

Abstract

In summary, we have showed that levels of COX-2 are increased in both TCC and RCC derived from urinary tract epithelium as well as gastrointestinal cancer. These results raised the possibility that selective inhibitors of COX-2 may be useful in the prevention or treatment of these diseases.

MeSH terms

Base Sequence
Carcinoma, Renal Cell / enzymology*
Carcinoma, Renal Cell / genetics
Carcinoma, Transitional Cell / enzymology
Carcinoma, Transitional Cell / genetics
Cyclooxygenase 2
DNA Primers
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Isoenzymes / genetics*
Kidney Neoplasms / enzymology*
Kidney Neoplasms / genetics
Membrane Proteins
Prostaglandin-Endoperoxide Synthases / genetics*
RNA, Messenger / genetics
Reverse Transcriptase Polymerase Chain Reaction
Urinary Bladder / enzymology*
Urinary Bladder Neoplasms / enzymology*
Urinary Bladder Neoplasms / genetics

Substances

DNA Primers
Isoenzymes
Membrane Proteins
RNA, Messenger
Cyclooxygenase 2
PTGS2 protein, human
Prostaglandin-Endoperoxide Synthases