Synthesis and structure--activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists

Bioorg Med Chem Lett. 2003 Apr 7;13(7):1341-4. doi: 10.1016/s0960-894x(03)00104-5.

Abstract

The synthesis and structure-activity relationships of a novel series of aroylpyrrole alkylamides as potent selective bradykinin B(2) receptor antagonists are described. Several members of this series display nanomolar affinity at the B(2) receptor and show activity in an animal model of antinociception.

MeSH terms

  • Alkanes / chemical synthesis*
  • Alkanes / pharmacology*
  • Analgesics / chemical synthesis
  • Analgesics / pharmacology
  • Animals
  • Bradykinin Receptor Antagonists*
  • Indicators and Reagents
  • Irritants / antagonists & inhibitors
  • Kaolin
  • Mice
  • Pain Measurement / drug effects
  • Pyrroles / chemical synthesis*
  • Pyrroles / pharmacology*
  • Receptor, Bradykinin B2
  • Structure-Activity Relationship

Substances

  • Alkanes
  • Analgesics
  • Bradykinin Receptor Antagonists
  • Indicators and Reagents
  • Irritants
  • Pyrroles
  • Receptor, Bradykinin B2
  • Kaolin