Successful treatment with cyclosporin A of myelodysplastic syndrome with erythroid hypoplasia associated with t(6;8)(q15;q22)

Cancer Genet Cytogenet. 2003 Jan 15;140(2):167-9. doi: 10.1016/s0165-4608(02)00655-6.

Abstract

We report a t(6;8)(q15;q22) in a patient with myelodysplastic syndrome (MDS) with erythroid hypoplasia. The patient was successfully treated with an immunosuppressive treatment with cyclosporin A, while the translocation was repeatedly detected as the sole anomaly with the percentages of positive cells ranging from 5% to 70%. To our knowledge, the t(6:8) has never been described in MDS.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anemia, Refractory / drug therapy*
  • Anemia, Refractory / pathology
  • Bone Marrow / pathology
  • Chromosome Painting
  • Chromosomes, Human, Pair 6 / ultrastructure*
  • Chromosomes, Human, Pair 8 / ultrastructure*
  • Cyclosporine / therapeutic use*
  • Erythropoiesis
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Translocation, Genetic*

Substances

  • Immunosuppressive Agents
  • Cyclosporine