Kar9 asymmetrical loading on spindle poles mediates proper spindle alignment in budding yeast

Dev Cell. 2003 Mar;4(3):289-90. doi: 10.1016/s1534-5807(03)00065-0.

Abstract

In the February 21 issue of Cell, demonstrate that asymmetrical loading of Kar9 onto astral microtubules (MTs) emanating from the bud-ward-directed spindle pole ensures delivery of this spindle pole to the bud. Kar9 mediates alignment of the spindle with the cell polarity axis through a Myo2-dependent mechanism that reorients astral MTs toward the bud.

Publication types

  • Comment
  • Review

MeSH terms

  • CDC28 Protein Kinase, S cerevisiae / genetics
  • CDC28 Protein Kinase, S cerevisiae / metabolism
  • Cell Division / physiology*
  • Cell Polarity / physiology*
  • Microtubules / metabolism
  • Nuclear Proteins / metabolism*
  • Protein Transport / physiology
  • Saccharomyces cerevisiae Proteins*
  • Saccharomycetales / cytology
  • Saccharomycetales / metabolism*
  • Spindle Apparatus / metabolism*

Substances

  • KAR9 protein, S cerevisiae
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins
  • CDC28 Protein Kinase, S cerevisiae