Application of genomics to toxicology research

Environ Health Perspect. 2002 Dec;110 Suppl 6(Suppl 6):919-23. doi: 10.1289/ehp.02110s6919.

Abstract

Traditional models of toxicity have relied on dissecting chemical action into pharmacokinetic and pharmacodynamic processes. However, the integration of genomic information with toxicology will enhance our basic understanding of these processes and significantly change the way we apply toxicological information to risk assessment and regulatory problems. In this article, we summarize the application of gene expression information and polymorphism discovery to four areas in toxicology: toxicity testing, cross-species extrapolation, understanding mechanism of action, and susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Environmental Pollutants / adverse effects
  • Forecasting
  • Gene Expression Regulation*
  • Genomics*
  • Humans
  • Oligonucleotide Array Sequence Analysis
  • Polymorphism, Genetic*
  • Toxicity Tests
  • Toxicology / trends*

Substances

  • Environmental Pollutants