Mild and efficient copper-catalyzed amination of aryl bromides with primary alkylamines

Org Lett. 2003 Mar 20;5(6):793-6. doi: 10.1021/ol0273396.

Abstract

[reaction: see text] An efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 degrees C in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amines / chemical synthesis*
  • Amines / chemistry
  • Bromine Compounds / chemical synthesis*
  • Catalysis
  • Copper / chemistry*

Substances

  • Amines
  • Bromine Compounds
  • Copper