Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women

Br J Cancer. 2003 Mar 10;88(5):675-8. doi: 10.1038/sj.bjc.6600761.

Abstract

A case-control study was performed to assess the potential influence of CYP19 Arg(264)Cys and CYP1B1 Leu(432)Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer risk (OR=1.5, 95% CI=1.1-2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alcohol Drinking / adverse effects*
  • Aromatase / genetics*
  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Base Sequence
  • Breast Neoplasms / epidemiology*
  • Breast Neoplasms / genetics
  • Case-Control Studies
  • Cytochrome P-450 CYP1B1
  • DNA Primers
  • Female
  • Humans
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Genetic*
  • Risk Factors

Substances

  • DNA Primers
  • Aromatase
  • Aryl Hydrocarbon Hydroxylases
  • CYP1B1 protein, human
  • Cytochrome P-450 CYP1B1