Formal catalytic asymmetric total synthesis of fostriecin

Kunihiko Fujii; Keisuke Maki; Motomu Kanai; Masakatsu Shibasaki

doi:10.1021/ol027528o

Formal catalytic asymmetric total synthesis of fostriecin

Org Lett. 2003 Mar 6;5(5):733-6. doi: 10.1021/ol027528o.

Authors

Kunihiko Fujii¹, Keisuke Maki, Motomu Kanai, Masakatsu Shibasaki

Affiliation

¹ Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

PMID: 12605502
DOI: 10.1021/ol027528o

Abstract

The common synthetic intermediate of a potent and promising anticancer agent, fostriecin, was synthesized using a unique method that combines four catalytic asymmetric reactions as shown above.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkenes / chemical synthesis*
Antibiotics, Antineoplastic / chemical synthesis*
Catalysis
Polyenes
Pyrones
Streptomyces / chemistry

Substances

Alkenes
Antibiotics, Antineoplastic
Polyenes
Pyrones
fostriecin