Abstract
Objective:
To examine the effect of AG490 on NK activity and lymphocyte transformation.
Methods:
Using MTT colorimetry to detect cell survival, NK activity and cell proliferation.
Results:
AG490 inhibited IL-2 and PHA induced peripheral blood mononuclear cell proliferation, and it inhibited NK activation.
Conclusion:
As an inhibitor of JAK, AG490 can influence the function of normal cells.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Division / drug effects
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Cells, Cultured
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Humans
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Interleukin-2 / immunology
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K562 Cells / immunology
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Killer Cells, Natural / immunology*
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Leukocytes, Mononuclear / drug effects
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Leukocytes, Mononuclear / immunology*
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Lymphocyte Activation / drug effects*
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Protein-Tyrosine Kinases / antagonists & inhibitors
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Tyrphostins / pharmacology*
Substances
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Interleukin-2
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Tyrphostins
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alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide
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Protein-Tyrosine Kinases