Interleukin-12 regulates chemokine gene expression during the early immune response to Leishmania major

Infect Immun. 2003 Mar;71(3):1587-9. doi: 10.1128/IAI.71.3.1587-1589.2003.

Abstract

Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2 were preferentially expressed in draining lymph nodes of resistant mice. Neutralization of interleukin 12 (IL-12) or gamma interferon in resistant mice resulted in decreased chemokine expression, while administration of IL-12 to susceptible mice resulted in an increase in the level of chemokine gene expression.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Chemokine CXCL10
  • Chemokines / genetics*
  • Chemokines, CXC / genetics
  • Gene Expression Regulation*
  • Interferon-gamma / biosynthesis
  • Interleukin-12 / physiology*
  • Leishmania major / immunology*
  • Leishmaniasis, Cutaneous / immunology*
  • Membrane Proteins / genetics
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H

Substances

  • Bacterial Proteins
  • Chemokine CXCL10
  • Chemokines
  • Chemokines, CXC
  • Membrane Proteins
  • Interleukin-12
  • Interferon-gamma