Auditing the pharmacological accounts for Hsp90 molecular chaperone inhibitors: unfolding the relationship between pharmacokinetics and pharmacodynamics

Mol Cancer Ther. 2003 Feb;2(2):131-8.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Comment

MeSH terms

  • Benzoquinones
  • Enzyme Inhibitors / pharmacokinetics
  • Enzyme Inhibitors / pharmacology
  • Gene Expression Regulation, Neoplastic
  • HSP90 Heat-Shock Proteins / antagonists & inhibitors*
  • Humans
  • Lactams, Macrocyclic
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism*
  • Protein Serine-Threonine Kinases / antagonists & inhibitors
  • Rifabutin / analogs & derivatives*
  • Rifabutin / pharmacokinetics*
  • Rifabutin / pharmacology*

Substances

  • Benzoquinones
  • Enzyme Inhibitors
  • HSP90 Heat-Shock Proteins
  • Lactams, Macrocyclic
  • Rifabutin
  • tanespimycin
  • Protein Serine-Threonine Kinases