Synthesis, catalytic properties and biological activity of new water soluble ruthenium cyclopentadienyl PTA complexes [(C5R5)RuCl(PTA)2] (R = H, Me; PTA = 1,3,5-triaza-7-phosphaadamantane)

Chem Commun (Camb). 2003 Jan 21:(2):264-5. doi: 10.1039/b210102e.

Abstract

The new water soluble ruthenium complexes [(C5R5)RuCl(PTA)2] (R = H, Me; PTA = 1,3,5-triaza-7-phosphaadamantane) were synthesised and characterised. Their evaluation as regioselective catalysts for hydrogenation of unsaturated ketones in aqueous biphasic conditions and as cytotoxic agents towards the TS/A adenocarcinoma cell line is briefly presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Catalysis
  • Cell Division / drug effects
  • Hydrogenation
  • Mice
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / pharmacology
  • Ruthenium / chemistry*
  • Ruthenium / pharmacology
  • Solubility
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Organometallic Compounds
  • Ruthenium