Abstract
Aim:
To investigate the cardiovascular active constituents of Radix Polygoni multiflori Preparata.
Methods:
Compounds were isolated from the water soluble extract with column chromatography of Sephadex, ODS and HPLC. The compounds were identified on the basis of spectral analysis (IR, EI-MS, FAB-MS, 1HNMR, 13CNMR, 2D-NMR) and phytochemical properties. Its inhibitory effect on the proliferation of bovine vascular smooth muscle cells were bioassayed in vitro.
Results:
One compound was isolated and identified as: 2,3,5,4'-tetrahydroxystilbene-2-O-(6"-O-alpha-D- glucopyranosyl)-beta-D-glucopyranoside.
Conclusion:
Compound I is a new compound with cardiovascular activity.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cattle
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Cell Division / drug effects
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Cells, Cultured
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Disaccharides / chemistry
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Disaccharides / isolation & purification*
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Disaccharides / pharmacology
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Molecular Conformation
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Molecular Structure
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Muscle, Smooth, Vascular / cytology
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Muscle, Smooth, Vascular / drug effects
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Myocytes, Smooth Muscle / cytology
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Myocytes, Smooth Muscle / drug effects
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Polygonum / chemistry*
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Stilbenes / chemistry
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Stilbenes / isolation & purification*
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Stilbenes / pharmacology
Substances
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2,3,5,4'-tetrahydroxystilbene-2-O-(6''-O-glucopyranosyl)glucopyranoside
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Disaccharides
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Stilbenes