The design and laboratory manufacture of "SUU-TYPE I" extra-luminal flow(ELF) hollow fibre membrane oxygenator are presented. The design is based on the O2 and CO2 transfer models in the cross-flow membrane oxygenator of Mockros and Pei. This paper also introduces the sketch of the membrane oxygenator, the structure of housing, the bundle of hollow fibres and the procedure of centrifugal potting. The self-made potting equipment and process of centrifugal potting are emphasized. The key know-how of centrifugal potting includes: (1) assuring the quality of the hollow fibre membrane material and the bundle; (2) calculating the quantity of potting material, polyurethane; (3) controlling reaction temperature; (4) removing gas from potting ends; (5) controlling rotation speed; (6) inserting the bundle in the house; (7) mastering the time of demoudling and cutting.