Abstract
Effects of cannabinoid compounds on neurons are predominantly mediated by the CB(1) cannabinoid receptor. Onset of signaling cascades in response to cannabimimetic drugs is triggered by the interaction of the cannabinoid receptor with G(i/o) proteins. Much work has been done to delineate the cannabinoid agonist-induced downstream signaling events; however, it remains to define the molecular basis of cannabinoid receptor-G protein interactions that stimulate these signaling pathways. In this review, we discuss several signal transduction pathways, focusing on studies that demonstrate the efficacy of CB(1) receptor agonists through G protein mediated pathways.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenylyl Cyclases / metabolism
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Amino Acid Sequence
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Animals
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Calcium Channels / drug effects
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Calcium Channels / metabolism
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Cannabinoids / metabolism
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Cell Differentiation / drug effects
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Cell Differentiation / physiology
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GTP-Binding Proteins / metabolism*
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Heterotrimeric GTP-Binding Proteins / metabolism
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Humans
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Mitogen-Activated Protein Kinases / metabolism
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Models, Molecular
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Molecular Sequence Data
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Nitric Oxide / biosynthesis
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Receptors, Cannabinoid
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Receptors, Drug / agonists
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Receptors, Drug / metabolism*
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Signal Transduction / physiology
Substances
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Calcium Channels
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Cannabinoids
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Receptors, Cannabinoid
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Receptors, Drug
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Nitric Oxide
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Mitogen-Activated Protein Kinases
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GTP-Binding Proteins
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Heterotrimeric GTP-Binding Proteins
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Adenylyl Cyclases