Human cutaneous leishmaniasis due to Leishmania infantum in the Sidi Bourouis focus (Northern Tunisia): epidemiological study and isoenzymatic characterization of the parasites

Acta Trop. 2003 Jan;85(1):83-6. doi: 10.1016/s0001-706x(02)00255-3.

Abstract

The authors report an increase of the number of case of cutaneous leishmaniasis in the Sidi Bourouis region community of Siliana Governorate (Tunisia), with 38 cases diagnosed in 6 months (1st November 2000-30th April 2001), contrary to its usual sporadic character. The isoenzymatic identification of 15 isolated strains emphasizes the role of the Leishmania infantum zymodeme MON-1 as an important factor in the genesis of the sporadic cutaneous leishmaniasis of Northern Tunisia. In fact it was isolated in 6 cases while L. infantum MON-24, the usual agent was isolated in 9 cases.

MeSH terms

  • Aged
  • Animals
  • Cells, Cultured
  • Child, Preschool
  • Female
  • Humans
  • Isoenzymes / analysis*
  • Leishmania infantum / enzymology*
  • Leishmania infantum / genetics
  • Leishmania infantum / isolation & purification*
  • Leishmaniasis, Cutaneous / drug therapy
  • Leishmaniasis, Cutaneous / epidemiology*
  • Leishmaniasis, Cutaneous / parasitology*
  • Male
  • Meglumine / pharmacology
  • Meglumine / therapeutic use
  • Meglumine Antimoniate
  • Organometallic Compounds / pharmacology
  • Organometallic Compounds / therapeutic use
  • Tunisia / epidemiology

Substances

  • Isoenzymes
  • Organometallic Compounds
  • Meglumine
  • Meglumine Antimoniate