Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa

Planta Med. 2002 Dec;68(12):1131-3. doi: 10.1055/s-2002-36358.

Abstract

From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of Evodia rutaecarpa together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4 Z,7 Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6 Z,9 Z)-6,9-pentadecadienyl]-4(1 H)-quinolone (4). They showed a dose-dependent DGAT inhibition with IC 50 values of 69.5 microM ( 1), 23.8 microM (2), 20.1 microM (3) and 13.5 mu (4).

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyltransferases / antagonists & inhibitors*
  • Alkaloids / pharmacology*
  • Animals
  • Diacylglycerol O-Acyltransferase
  • Evodia*
  • Fruit / chemistry
  • Male
  • Microsomes, Liver / drug effects
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Quinolones / chemistry
  • Quinolones / isolation & purification
  • Quinolones / pharmacology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • 1-methyl-2-(4,7-tridecadienyl)-4(1H)-quinolone
  • 1-methyl-2-(6,9-pentadecadienyl)-4(1H)-quinolone
  • 1-methyl-2-tetradecyl-4(1H)-quinolone
  • Alkaloids
  • Plant Extracts
  • Quinolones
  • Acyltransferases
  • Diacylglycerol O-Acyltransferase