Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide-derived phosphatase inhibitors

Angew Chem Int Ed Engl. 2002 Jan 18;41(2):307-11. doi: 10.1002/1521-3773(20020118)41:2<307::aid-anie307>3.0.co;2-1.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / chemical synthesis*
  • 4-Butyrolactone / chemistry
  • 4-Butyrolactone / pharmacology
  • Biological Products*
  • Cell Survival / drug effects
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Oxidation-Reduction
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tumor Cells, Cultured / enzymology
  • cdc25 Phosphatases / antagonists & inhibitors*

Substances

  • Biological Products
  • Enzyme Inhibitors
  • cdc25 Phosphatases
  • dysidiolide
  • 4-Butyrolactone