Ginsenoside Rb1 enhances peripheral nerve regeneration across wide gaps in silicone rubber chambers

Int J Artif Organs. 2002 Nov;25(11):1103-8. doi: 10.1177/039139880202501110.

Abstract

Silicone rubber chambers filled with collagen containing ginsenoside Rb1 (GRb1) were used to repair lesioned rat sciatic nerves with 15-mm gaps between stumps. Six weeks after implantation, histology of the nerve regenerated in the chambers filled with GRb1 and collagen contained larger axons than those in the chambers with collagen only. This study showed that the GRb1 could exert a positive influence on nerve regeneration when using silicone rubber tubes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Ginsenosides / pharmacology*
  • Male
  • Nerve Regeneration / drug effects*
  • Nerve Regeneration / physiology
  • Peripheral Nerves / drug effects
  • Peripheral Nerves / pathology
  • Prostheses and Implants
  • Rats
  • Rats, Sprague-Dawley
  • Reference Values
  • Sciatic Nerve / drug effects*
  • Sciatic Nerve / injuries*
  • Sciatic Nerve / pathology
  • Sensitivity and Specificity
  • Silicone Elastomers / pharmacology*

Substances

  • Ginsenosides
  • Silicone Elastomers
  • ginsenoside Rb1