A 42-year-old woman underwent breast conserving operation with irradiation for Stage I (T1 N0 M0) breast cancer at the 12 o'clock axis of her right breast. At six years after surgery, a solitary local recurrent tumor (1.2 cm in diameter) was found at the 2 o'clock axis of her right breast. No metastases were found at other sites. By the desire of the patient to conserve her breast, we performed re-lumpectomy with surgical margin (2 cm) and reconstructed with a rectus abdominis musculocutaneus flap to fill the large defect of breast tissue. One year and 5 months after surgery, the patient was doing well without recurrence, and was satisfied with the cosmetic effect.