An ensemble method for identifying regulatory circuits with special reference to the qa gene cluster of Neurospora crassa

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16904-9. doi: 10.1073/pnas.262658899. Epub 2002 Dec 11.

Abstract

A chemical reaction network for the regulation of the quinic acid (qa) gene cluster of Neurospora crassa is proposed. An efficient Monte Carlo method for walking through the parameter space of possible chemical reaction networks is developed to identify an ensemble of deterministic kinetics models with rate constants consistent with RNA and protein profiling data. This method was successful in identifying a model ensemble fitting available RNA profiling data on the qa gene cluster.

MeSH terms

  • Genes, Fungal*
  • Genes, Regulator*
  • Monte Carlo Method
  • Multigene Family
  • Neurospora crassa / genetics*
  • Neurospora crassa / metabolism
  • Quinic Acid / metabolism*
  • RNA, Messenger / analysis

Substances

  • RNA, Messenger
  • Quinic Acid