Progressive multifocal leukoencephalopathy after stem cell transplantation, unsuccessfully treated with cidofovir

Bone Marrow Transplant. 2002 Dec;30(12):963-6. doi: 10.1038/sj.bmt.1703704.

Abstract

We report a patient with progressive multifocal leukoencephalopathy (PML) after autologous stem cell transplantation (SCT) for non-Hodgkin's lymphoma (NHL). This is an unusual association, and to date only seven cases have been reported. This is the first case of PML after SCT treated with cidofovir, and the fifth case treated with this drug in a patient without human immunodeficiency virus (HIV) infection. In the previous four patients treated with cidofovir the outcome was discouraging, as was the case in this patient.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Antiviral Agents / therapeutic use*
  • Brain / virology
  • Cidofovir
  • Combined Modality Therapy
  • Cytosine / analogs & derivatives*
  • Cytosine / therapeutic use*
  • Fatal Outcome
  • HIV Seronegativity
  • Humans
  • Immunocompromised Host
  • JC Virus / isolation & purification
  • Leukoencephalopathy, Progressive Multifocal / drug therapy*
  • Leukoencephalopathy, Progressive Multifocal / etiology
  • Leukoencephalopathy, Progressive Multifocal / virology
  • Lymphoma, Mantle-Cell / complications
  • Lymphoma, Mantle-Cell / drug therapy
  • Lymphoma, Mantle-Cell / therapy
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Organophosphonates*
  • Organophosphorus Compounds / therapeutic use*
  • Peripheral Blood Stem Cell Transplantation / adverse effects*
  • Transplantation, Autologous / adverse effects
  • Treatment Failure

Substances

  • Antiviral Agents
  • Organophosphonates
  • Organophosphorus Compounds
  • Cytosine
  • Cidofovir