Abstract
Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antigen Presentation*
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Antigens, Bacterial / immunology*
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Antigens, CD / physiology
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CD8-Positive T-Lymphocytes / immunology*
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Cell Line
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Dendritic Cells / physiology
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HLA Antigens / physiology*
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HLA-E Antigens
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Histocompatibility Antigens Class I / physiology*
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Humans
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Interferon-gamma / biosynthesis
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Lectins, C-Type / physiology
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Mycobacterium tuberculosis / immunology*
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NK Cell Lectin-Like Receptor Subfamily D
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Receptors, Immunologic / physiology
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Receptors, Natural Killer Cell
Substances
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Antigens, Bacterial
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Antigens, CD
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HLA Antigens
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Histocompatibility Antigens Class I
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Lectins, C-Type
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NK Cell Lectin-Like Receptor Subfamily D
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Receptors, Immunologic
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Receptors, Natural Killer Cell
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Interferon-gamma