Abstract
A new alkaloid, pipersintenamide ( 1), together with fourteen known compounds, have been isolated from the whole plant of Piper sintenense. The structures of these compounds were elucidated by spectroscopic analysis. Pipersintenamide, sintenpyridone, sarmentine, and 1-(3,4-methylenedioxyphenyl)-1 E-dodecene at 20 microg/ml exhibited effective cytotoxicities (cell survival < 15 %) against CCRF-CEM, HL-60, PC-3, and HA22T cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / pharmacology*
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Alkenes / therapeutic use
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Animals
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / therapeutic use
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Cell Division / drug effects*
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Cell Survival / drug effects*
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Muscle, Smooth, Vascular / cytology
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Muscle, Smooth, Vascular / drug effects
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Phytotherapy*
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Piper*
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Piperidines / pharmacology*
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Piperidines / therapeutic use
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Rats
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Tumor Cells, Cultured / drug effects
Substances
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Alkenes
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Antineoplastic Agents, Phytogenic
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Piperidines
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Plant Extracts
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pipersintenamide