Inhibition by ajoene of skin-tumor promotion in mice

Biosci Biotechnol Biochem. 2002 Oct;66(10):2221-3. doi: 10.1271/bbb.66.2221.

Abstract

Ajoene, a major compound containing sulfur in oil-macerated garlic products, inhibited in a two-stage carcinogenesis test on mouse skin. Treatment with ajoene suppressed skin tumor formation, depending on the amount. In particular, the group treated with 250 microg of ajoene had only 4.9% the number of tumors per mouse compared with the control group at 18 weeks.

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene / metabolism
  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Carcinogens / antagonists & inhibitors*
  • Carcinogens / metabolism
  • Carcinogens / toxicity
  • Disulfides / pharmacology*
  • Garlic / chemistry
  • Male
  • Mice
  • Mice, Inbred ICR
  • Plant Extracts / pharmacology*
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / prevention & control*
  • Solvents
  • Sulfoxides
  • Tetradecanoylphorbol Acetate / antagonists & inhibitors
  • Tetradecanoylphorbol Acetate / toxicity

Substances

  • Antineoplastic Agents, Phytogenic
  • Carcinogens
  • Disulfides
  • Plant Extracts
  • Solvents
  • Sulfoxides
  • 9,10-Dimethyl-1,2-benzanthracene
  • ajoene
  • Tetradecanoylphorbol Acetate