Cytoskeleton: what does GTP do for septins?

Timothy J Mitchison; Christine M Field

doi:10.1016/s0960-9822(02)01295-2

Cytoskeleton: what does GTP do for septins?

Curr Biol. 2002 Nov 19;12(22):R788-90. doi: 10.1016/s0960-9822(02)01295-2.

Authors

Timothy J Mitchison¹, Christine M Field

Affiliation

¹ Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115-5731, USA.

PMID: 12445407
DOI: 10.1016/s0960-9822(02)01295-2

Abstract

The recent observation of GTP-promoted polymerization of a single septin polypeptide suggests that this protein has tubulin-like biochemical properties. This model cannot, however, explain the GTP-biochemistry of heteromeric septin complexes from cytosol.

Publication types

Comment
Review

MeSH terms

Animals
Cytoskeleton / physiology*
GTP-Binding Proteins / metabolism*
Guanosine Triphosphate / metabolism*
Mammals
Protein Folding
Recombinant Proteins / metabolism

Substances

Recombinant Proteins
Guanosine Triphosphate
GTP-Binding Proteins