Does a preexisting anxiety disorder predict response to paroxetine in irritable bowel syndrome?

Psychosomatics. 2002 Nov-Dec;43(6):451-5. doi: 10.1176/appi.psy.43.6.451.

Abstract

Irritable bowel syndrome (IBS) is the most common disorder in patients seen by gastroenterologists. Twenty subjects with IBS diagnosed with the Rome criteria were treated for 12 weeks with 20-40 mg/day of paroxetine (mean dose=31 mg/day). At baseline, 10 patients had a lifetime history of an anxiety disorder, and 10 patients did not have such a history. Both groups had similar improvement in abdominal pain, constipation, diarrhea, incomplete emptying, and bloating/ abdominal distension. Paroxetine was very well tolerated.

MeSH terms

  • Adult
  • Anxiety Disorders / drug therapy*
  • Anxiety Disorders / psychology
  • Colonic Diseases, Functional / drug therapy*
  • Colonic Diseases, Functional / psychology
  • Comorbidity
  • Female
  • Humans
  • Male
  • Paroxetine / therapeutic use*
  • Psychiatric Status Rating Scales
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*
  • Self Disclosure
  • Severity of Illness Index

Substances

  • Serotonin Uptake Inhibitors
  • Paroxetine