Comparison of three rat models of cerebral vasospasm

Am J Physiol Heart Circ Physiol. 2002 Dec;283(6):H2551-9. doi: 10.1152/ajpheart.00616.2002.

Abstract

A substantial number of rat models have been used to research subarachnoid hemorrhage-induced cerebral vasospasm; however, controversy exists regarding which method of selection is appropriate for this species. This study was designed to provide extensive information about the three most popular subarachnoid hemorrhage rat models: the endovascular puncture model, the single-hemorrhage model, and the double-hemorrhage model. In this study, the basilar artery and posterior communicating artery were chosen for histopathological examination and morphometric analysis. Both the endovascular puncture model and single-hemorrhage model developed significant degrees of vasospasm, which were less severe when compared with the double-hemorrhage model. The endovascular puncture model and double-hemorrhage model both developed more vasospasms in the posterior communicating artery than in the basilar artery. The endovascular puncture model has a markedly high mortality rate and high variability in bleeding volume. Overall, the present study showed that the double-hemorrhage model in rats is a more suitable tool with which to investigate mechanism and therapeutic approaches because it accurately correlates with the time courses for vasospasm in humans.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Animals
  • Basilar Artery / pathology
  • Basilar Artery / physiopathology
  • Disease Models, Animal*
  • Disease Progression
  • Male
  • Posterior Cerebral Artery / pathology
  • Posterior Cerebral Artery / physiopathology
  • Rats
  • Rats, Sprague-Dawley
  • Reproducibility of Results
  • Subarachnoid Hemorrhage / complications
  • Subarachnoid Hemorrhage / pathology
  • Subarachnoid Hemorrhage / physiopathology*
  • Survival Rate
  • Time Factors
  • Vasospasm, Intracranial / etiology
  • Vasospasm, Intracranial / pathology
  • Vasospasm, Intracranial / physiopathology*