Clinical features and comorbidity of mood fluctuations in Parkinson's disease

J Neuropsychiatry Clin Neurosci. 2002 Fall;14(4):438-42. doi: 10.1176/jnp.14.4.438.

Abstract

Parkinson's disease (PD) patients commonly develop fluctuations in their motor responses to levodopa within several years of initiation of treatment; some also develop nonmotor fluctuations. The authors performed a case-control study comparing the frequency of comorbid symptoms in 70 PD patients who experienced clinically apparent mood changes during their motor "on" or "off" states with two control groups with no mood fluctuations. Mood fluctuators had significantly younger age at onset and longer disease duration and were significantly more likely to have dementia, psychosis, clinical depression, and motor complications. This association remained after removing effects of age and disease duration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Comorbidity
  • Female
  • Humans
  • Hypokinesia / epidemiology
  • Male
  • Middle Aged
  • Mood Disorders / diagnosis
  • Mood Disorders / epidemiology
  • Mood Disorders / psychology*
  • Parkinson Disease / epidemiology
  • Parkinson Disease / psychology
  • Severity of Illness Index
  • Tremor / epidemiology