Abstract
Developing axons are guided to their targets by chemoattractive and chemorepulsive ligands. Ledda et al., in this issue of Neuron, demonstrate that the target-derived receptor glial cell line-derived neurotrophic factor receptor alpha1 (GFRalpha1) can also act in trans as an axon guidance molecule for neurons.
MeSH terms
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Animals
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Cell Communication / physiology*
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Cell Differentiation / physiology*
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Chemotaxis / physiology*
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Cues
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Drosophila Proteins*
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Glial Cell Line-Derived Neurotrophic Factor
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Glial Cell Line-Derived Neurotrophic Factor Receptors
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Growth Cones / metabolism*
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Humans
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Nerve Growth Factors / metabolism
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Nervous System / embryology*
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Nervous System / metabolism
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Proto-Oncogene Proteins / metabolism*
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Proto-Oncogene Proteins c-ret
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Receptor Protein-Tyrosine Kinases / metabolism*
Substances
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Drosophila Proteins
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GDNF protein, human
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GFRA1 protein, human
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Glial Cell Line-Derived Neurotrophic Factor
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Glial Cell Line-Derived Neurotrophic Factor Receptors
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Nerve Growth Factors
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-ret
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Receptor Protein-Tyrosine Kinases
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Ret protein, Drosophila