Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

Ann Rheum Dis. 2002 Nov;61 Suppl 2(Suppl 2):ii13-8. doi: 10.1136/ard.61.suppl_2.ii13.

Abstract

There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenoviridae / genetics
  • Antigen Presentation
  • Arthritis, Rheumatoid / immunology
  • Arthritis, Rheumatoid / therapy*
  • Cell Culture Techniques
  • Dendritic Cells / immunology
  • Genetic Vectors
  • Humans
  • I-kappa B Proteins / genetics
  • Immunity, Cellular
  • Lymphocyte Culture Test, Mixed
  • NF-kappa B / antagonists & inhibitors*
  • NF-kappa B / physiology
  • Synovial Membrane / immunology

Substances

  • I-kappa B Proteins
  • NF-kappa B