The von Hippel-Lindau tumor suppressor complex and regulation of hypoxia-inducible transcription

Adv Cancer Res. 2002:85:1-12. doi: 10.1016/s0065-230x(02)85001-1.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenocarcinoma, Clear Cell / metabolism
  • Carcinoma, Renal Cell / metabolism
  • Cell Cycle Proteins / physiology
  • Cell Hypoxia / genetics*
  • Cell Hypoxia / physiology
  • Cullin Proteins*
  • Elongin
  • Enzyme Activation
  • Gene Expression Regulation / genetics
  • Gene Expression Regulation / physiology*
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Kidney Neoplasms / metabolism
  • Ligases / genetics
  • Ligases / physiology*
  • Macromolecular Substances
  • Neoplasm Proteins / physiology
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Pathologic / metabolism
  • Procollagen-Proline Dioxygenase / physiology
  • Protein Processing, Post-Translational
  • Protein Subunits
  • Transcription Factors / chemistry
  • Transcription Factors / metabolism
  • Transcription Factors / physiology
  • Tumor Suppressor Proteins*
  • Ubiquitin / metabolism
  • Ubiquitin-Protein Ligases
  • Von Hippel-Lindau Tumor Suppressor Protein

Substances

  • CUL2 protein, human
  • Cell Cycle Proteins
  • Cullin Proteins
  • Elongin
  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Macromolecular Substances
  • Neoplasm Proteins
  • Protein Subunits
  • Transcription Factors
  • Tumor Suppressor Proteins
  • Ubiquitin
  • Procollagen-Proline Dioxygenase
  • Ubiquitin-Protein Ligases
  • Von Hippel-Lindau Tumor Suppressor Protein
  • Ligases
  • VHL protein, human