PTEN function in mammalian cell size regulation

Stéphanie Backman; Vuk Stambolic; Tak Mak

doi:10.1016/s0959-4388(02)00354-9

PTEN function in mammalian cell size regulation

Curr Opin Neurobiol. 2002 Oct;12(5):516-22. doi: 10.1016/s0959-4388(02)00354-9.

Authors

Stéphanie Backman¹, Vuk Stambolic, Tak Mak

Affiliation

¹ Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, 610 University Avenue, Toronto, Canada. sbackman@uhnres.utoronto.edu

PMID: 12367630
DOI: 10.1016/s0959-4388(02)00354-9

Abstract

The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation / genetics
Cell Division / genetics
Cell Size / genetics
Hamartoma Syndrome, Multiple / genetics
Humans
Neurons / cytology*
PTEN Phosphohydrolase
Phosphoric Monoester Hydrolases / genetics*
Phosphoric Monoester Hydrolases / metabolism*
Tumor Suppressor Proteins / genetics*
Tumor Suppressor Proteins / metabolism*

Substances

Tumor Suppressor Proteins
Phosphoric Monoester Hydrolases
PTEN Phosphohydrolase
PTEN protein, human